Notes
(1) Information on specific commercial uses of pharmaceutical and industrial crop products is not available to the public. Some have potential applications for human or veterinary medicine but none has been approved by the Food and Drug Administration, which regulates drugs.
(2) Most of these products have been commercialized through Sigma Chemical Company, which specializes in products for research and diagnostic purposes. AproliZean and B-glucuronidase have been commercialized according to ProdiGene documents, but their current availability is unknown.
(3) Unlike pharmaceutical corn, tobacco itself is not genetically engineered. Rather, a tobacco mosaic virus is engineered to contain a gene for aprotinin. The engineered virus then produces aprotinin in tobacco plants infected with the virus.
Sources of information about commercialization:
1. Aprotinin (corn) - Announcement of commercial production, 7/16/02. "ProdiGene Begins Scale-Up of Aprotinin From Plants." http://www.biospace.com/news_story.cfm?StoryID=9388520&full=1
2. Aprotinin (tobacco) - Manufacturing agreement, 3/8/04. "Large Scale Biology Corporation (LSBC) And Sigma-Aldrich Announce An Agreement To Manufacture And Distribute Plant-Produced Recombinant Aprotinin." http://www.biospace.com/news_story.cfm?StoryID=15379820&full=1
3. Avidin - Product launch, 6/10/97. "Sigma Chemical Co. and ProdiGene Inc. Launch First Protein Products From Transgenic Plants." http://www.prodigene.com/news_releases/97-06-10_sigma.html
4. B-glucuronidase (GUS) - Product launch, 6/10/97. "Sigma Chemical Co. and ProdiGene Inc. Launch First Protein Products From Transgenic Plants." http://www.prodigene.com/news_releases/97-06-10_sigma.html
5. Trypsin - Manufacturing agreement, 10/9/02. "ProdiGene and Sigma-Aldrich Announce an Agreement to Manufacture and Distribute Recombinant Maize-Derived Trypsin." http://www.findarticles.com/p/articles/mi_m0EIN/is_2002_Oct_9/ai_92650944/print
6. Lactoferrin - No information about commercialization found, but product is available from Sigma at www.sigmaaldrich.com.
7. Lysozyme - No information about commercialization found, but product is available from Sigma at www.sigmaaldrich.com.
See also websites of ProdiGene (www.prodigene.com), Large Scale Biology (www.lsbc.com), and Sigma-Aldrich (http://www.sigmaaldrich.com/). |
